RED CELLS, IRON, AND ERYTHROPOIESIS Erythrocyte microparticles can induce kidney vaso-occlusions in a murine model of sickle cell disease
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چکیده
1Paris Center for Cardiovascular Research, Inserm Unité Mixte de Recherche (UMR)s-970, Hôpital Européen Georges Pompidou, et Université Paris Descartes, Sorbonne Paris Cité, Paris, France; 2Université Paris Diderot, Sorbonne Paris Cité, Inserm, UMRs-965, Assistance Publique des Hopitaux de Paris, Hôpital Lariboisière, Physiologie Clinique-Explorations-Fonctionnelles, Paris, France; 3Centre National de Recherche Scientifique UMRs-6214 et Inserm U1083, CHU Angers, Université d’Angers, Angers, France
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Inhibition of leukocyte adhesion to the vascular endothelium represents a novel and important approach for decreasing sickle cell disease (SCD) vaso-occlusion. Using a humanized SCD–mouse-model of tumor necrosis factor–induced acute vaso-occlusion, we herein present data demonstrating that short-term administration of either hydroxyurea or the phosphodiesterase 9 (PDE9) inhibitor, BAY736691, si...
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Sickle cell disease is characterized by painful vaso-occlusive crises during which abnormal interactions between erythroid adhesion molecules and vesselwall proteins are thought to play a critical role. Hydroxyurea, the only drug with proven benefit in sickle cell disease, diminishes these interactions, but its mechanism of action is not fully understood. We report that, under hydroxyurea, expr...
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Kidneys are the main site of production of the hormone erythropoietin (EPO) that is the major regulator of erythropoiesis, or red blood cell production. EPO level is normally controlled by a negative feedback mechanism in the kidneys, but patients with chronic kidney disease (CKD) do not produce sufficient levels of EPO to maintain blood hemoglobin concentration. In order to prevent anemia, pat...
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تاریخ انتشار 2012